You are here

Functional Markers for MSC Therapy in Osteoarthritis

A new STEM CELLS article from the lab of Anthony P. Hollander (University of Liverpool, UK) has shown that mesenchymal stem cell (MSC) chondrogenesis represents a transient property that is lost as cells age in vitro, whereas trophic repair potency is maintained until MSCs cease to grow. Salerno et al. note that their findings highlight the importance of defining the intended mode of action when preparing MSCs for injection into osteoarthritic joints and demonstrate that the development of injectable MSC therapies for osteoarthritis must take into account the transient nature of chondrogenic potency relative to their sustained trophic potency with increasing passages. Overall, specific strategies should be adopted to exploit one or other of these mechanisms of action.