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Fluid Shear Stress Promotes ESC Pluripotency

Fluid shear stress generated in bioreactors can modulate cell behavior, pluripotency, and differentiation capability. In a new STEM CELLS study, researchers led by Derrick E. Rancourt (University of Calgary, Alberta, Canada) reveal that fluid shear stress supports mouse embryonic stem cell (ESC) pluripotency and obviates the need to add leukemia inhibitory factor (LIF) to bioreactor culture. Nath et al. termed this phenomenon as mechanopluripotency and demonstrated the overall importance of β‐catenin translocation to the nucleus and adherens junction‐associated vinculin expression.