Fighting Fibrosis with iPSC-derived Macrophages

Improved treatments for diseased or degenerated tissues and organs are greatly needed; now, researchers led by Dan S. Kaufman (University of California, San Diego, La Jolla, California, USA) demonstrate the ability to efficiently derive macrophages from human induced pluripotent stem cells (iPSCs) with the ability to improve liver fibrosis in a mouse xenograft model. This new STEM CELLS study from Pouyanfard et al. supports the clinical translation of iPSC-derived cells to treat diverse fibrotic diseases.