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Fat Grafting Rescues Radiation-induced Limb Contracture

Radiation therapy stimulates progressive and pathological soft tissue fibrosis, which distorts tissue form and negatively influences function. Researchers from the lab of Derrick C. Wan (Stanford University School of Medicine, CA, USA) knew of the regenerative effects of fat grafting, and that this methodology could reduce and even reverse radiation‐induced fibrosis of the skin. In their new STEM CELLS article, Borrelli et al. describe a mouse model of radiation‐induced hind limb contracture and establish that fat grafting enhances skin vascularity, reduces skin fibrosis, and improves the extensibility of the affected limb.