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Exosomal CNP Promotes Recovery of Damaged Brain

Mesenchymal stem cells (MSCs) have vast therapeutic potential for the treatment for neurological diseases and damage, with many of their effects mediated by components of the stem cell secretome. Researchers led by Hua‐Jung Li (National Health Research Institutes, Zhunan, Taiwan) found that prostaglandin E2 receptor 4 (EP4)-induced MSC extracellular vesicles/exosomes has an elevated ability to rescue damaged brain functions and established the requirement of elevated 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase (CNP) levels for this effect. Overall, this new STEM CELLS Translational Medicine article from Chen et al. suggests that CNP modulation represents a potential target for treating brain damage and neural degeneration diseases and further underscore the power of MSC-derived paracrine-acting factors.