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Ex Vivo Expansion of Adult HSCs With Valproic Acid

A new article from researchers led by Eran Zimran (Hadassah University Center, Jerusalem, Israel) recently described how the transplantation of ex vivo valproic acid (VPA)-treated adult mobilized peripheral blood and bone marrow hematopoietic stem cells (HSCs) into immune‐deficient mice led to non-biased long‐term multilineage hematopoietic cell engraftment, including T cells. The authors believe that their findings support the use of VPA, a histone deacetylase inhibitor, in ex vivo HSC expansion for future gene modification strategies. For all the details, see STEM CELLS Translational Medicine now!