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Evaluating Tissue‐specific MSC Interactions with B cells

While human mesenchymal stem cells (MSCs) possess clinically relevant immunomodulatory capabilities, studies regarding B cells remain surprisingly rare. In a new STEM CELLS Translational Medicine article, researchers led by B. Linju Yen (National Health Research Institutes (NHRI), Zhunan, Taiwan) report on their investigation of the in vitro and in vivo interactions of pan‐peripheral B lymphocyte populations with MSCs from the bone marrow and the placenta. Lee et al. establish that the different MSCs types each modulate B‐cell proliferation and differentiation in a distinct manner, thereby highlighting the importance of understanding tissue‐specific differences to achieve enhanced MSC therapy outcomes.