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Enteric Neurons from Pre-migratory NCSCs

Cell candidates for enteric nervous system regeneration and Hirschsprung's disease are mostly based on the derivation or induction of enteric neural stem cells. Now, researchers led by Yi Dong (East China Normal University, Shanghai) and Jinfa Tou and Wei Chen (Zhejiang University, Hangzhou, China) report that pre-migratory neural crest stem cells (NCSCs) populate the adult mouse colon, differentiate into enteric neurons, and mediate neuron-dependent peristalsis in tissue‐engineered intestine. Overall, this STEM CELLS Translational Medicine article from Yuan et al. suggests that cell candidates for enteric nervous system regeneration may be expanded to include the NCSCs of non-enteric origin.