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Enhancing Cone and Rod Generation from hPSCs

The generation of retinal organoids from human pluripotent stem cells (hPSCs) provides an in vitro approach to disease modeling and replacement therapies; however, the efficiency of described protocols for the generation of retinal organoids remains variable, resulting in the emergence of all retinal cell types, including photoreceptors, but in different ratios and at different maturation stages. Now, a new study from the laboratory of Majlinda Lako (Newcastle University, Newcastle, UK) shows that the addition of retinoic acid in combination with triiodothyronine, levodopa, or DAPT at specific time intervals promotes cone and rod formation. For all the fine print, see STEM CELLS now!