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Engineering Hypoimmunogenic Pluripotent Stem Cells

In a recent STEM CELLS article, researchers led by Lin Ma and Xiaoqing Zhang (Tongji University School of Medicine, Shanghai, China) describe the construction of hypoimmunogenic human pluripotent stem cells (hPSCs) by targeting the beta‐2 microglobulin (B2M) and human leukocyte antigen- (HLA-) G proteins. Shi et al. report that engineered hypoimmunogenic hPSCs protect against immunotoxicity mediated by CD8+ T cells and natural killer cells; furthermore, they safeguarded environments with low immunogenicity by lowering inflammatory cytokines secretion. Overall, hypoimmunogenic hPSCs could serve as invaluable cell sources for regenerative purposes.