You are here

Engineering, β‐cell function, and Diabetes

While superficially a disease of insulin secretion and sugar metabolism, the deeper complexities of diabetes necessitate advanced engineered strategies to uncover new treatment approaches. In vitro models of β‐cells and insulin secretion in a human‐specific context have emerged as powerful tools to study diabetes. In a recent concise review published in STEM CELLS, Phillip L. Lewis and James M. Wells (Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA) discuss several advances, including different sources of insulin‐secreting cells, organ‐on‐a‐chip models, and high throughput strategies designed to deepen our understanding of β‐cell biology and to better treat disease.