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EEMs and Exosomes Promote Ligament Healing

A new STEM CELLS article from the labs of Ray Vanderby and Peiman Hematti (University of Wisconsin‐Madison, Madison, WI, USA) described how exosomes and exosome‐educated macrophages (EEMs) improve ligament healing in a normally scar‐forming tissue via different mechanisms. Chamberlain et al. report that EEMs reduce inflammation and improve ligament strength, while exosomes decrease scar size and increase collagen organization and production. The authors also underscore their findings' clinical relevance, as both EEMs and exosomes represent a safe and effective means to modulate regeneration.

For more, see the Stem Cells Portal Press Release "Study points way to possible new treatment for ligament injuries" at