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DUSP5 Promotes MSC Osteogenesis

DUSP5 plays a crucial regulatory role in the signaling pathway transduction by dephosphorylating phosphoserine/phosphothreonine and phosphotyrosine; however, the participation of DUSP5 in osteogenesis remains unclear. In a recent STEM CELLS article, researchers led by Yongsheng Zhou and Ping Zhang (Peking University, Beijing, China) demonstrate that DUSP5 promotes the osteoblastic differentiation of mesenchymal stem cells (MSCs) by activating SMAD1 signaling in an SCP1/2 dependent manner. Furthermore, Liu et al. report that the linker region of DUSP5 may represent a novel chemically modifiable target for the control of MSC fate choice and improved osteoporosis treatment.