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DNMT3B Controls Metabolic Flux of hESCs

A new study from the laboratory of Judith Staerk (University of Oslo, Norway) has revealed a novel link between DNA methyltransferase (DNMT) 3B and metabolic flux in human embryonic stem cells (hESCs). In their new STEM CELLS study, Cieslar‐Pobuda et al. discovered that the loss of DNMT3B disrupted mitochondrial fusion and fission balance, reduced mitochondrial DNA levels, and elicited a switch from glycolysis to oxidative phosphorylation. Furthermore, DNMT3B loss led to the overexpression and hyperactivity of isocitrate dehydrogenases and buildup of α‐ketoglutarate and the significant upregulation of transcription factors during early neural differentiation.