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Differentiation Variability to Retinal Organoids

Using two different differentiation approaches involving either BMP4 or IGF1 signaling pathways, researchers led by Lyle Armstrong (Newcastle University, UK) recently derived retinal organoids from three human induced pluripotent stem cell (iPSC) lines. Chichagova et al. achieved the generation of retinal organoids using both methods; however, the two different approaches produced a bias toward certain retinal cell types. Overall, the authors urge careful consideration when choosing a differentiation protocol and note that overall efficiency retinal organoids generation depends on the modulated signaling pathways. For all the fine print, see STEM CELLS now!