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Developing Stem Cell Therapies for Diabetes

A new Perspectives article from researchers led by Timothy J. Kieffer (University of British Columbia, Vancouver, Canada) discusses the potential of stem cell-derived pancreatic progenitors and more matured insulin-producing cells to treat diabetes. In their recent STEM CELLS Translational Medicine article, Iworima et al. report on the need for rigorous bioprocess parameter optimization and identify some critical process parameters and strategies that may influence the critical quality attributes of the cells to facilitate scalable manufacturing of human pluripotent stem cell-derived pancreatic endocrine cells.