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Cxcr5 Regulates Neurogenesis in the Aged Brain

Results of a new study from researchers led by Henrik Ahlenius (Lund University, Lund, Sweden) now establish how inflammatory mediators elicit profound and specific effects on neurogenesis without direct action on neural stem and progenitor cells. Writing in STEM CELLS, Fritze et al. report that the loss of Cxcr5 influences systemic and local cytokine expression, which prompts alterations to neuroblast proliferation and migration in the aged brain. Therefore, the authors hypothesize that naturally occurring alterations in systemic and local inflammation may contribute to neurogenic decline during aging and that therapeutic interventions targeting cytokine signaling in inflammation could affect neurogenesis in the aged brain.