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CXCR4 Required for HSPC Maintenance

A recent STEM CELLS study from the laboratories of Pratibha Singh and Louis M. Pelus (Indiana University School of Medicine, Indianapolis, IN, USA) recently identified how the bone marrow niche intrinsic CXCR4‐SDF‐1 axis supports hematopoietic stem and progenitor cell (HSPC) maintenance and retention under steady‐state conditions and also promotes early hematopoietic recovery after myeloablation. The team´s findings suggest that targeted modulation of CXCR4 signaling in the bone marrow niche may alleviate irradiation/chemotherapy‐induced bone marrow stromal damage and enhance blood cell production in patients undergoing stem cell transplantation for several hematological complications including leukemia, lymphoma, and aplastic anemia, as well as metabolic disorders such as diabetes.