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Corneal Stromal Stem Cell Therapy

Corneal scarring can occur as a result of a range of corneal disorders, including infections, trauma, and genetic diseases, and represents one of the leading causes of blindness worldwide. Corneal stromal stem cells can be easily retrieved and cultured from patient or donor eyes and then employed to regenerate the corneal stromal extracellular matrix, which is essential for maintaining corneal transparency. Now, a new STEM CELLS Translational Medicine study from Vincent M. Borderie (Sorbonne Université, Paris, France) describes the therapeutic effect of these adult stem cells in a mouse model of corneal opacification by demonstrating the ability of corneal stromal stem cells to promote regeneration of transparent stromal tissue after corneal scarring induced by liquid nitrogen.