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The Convergence of Cell Pharmacology and Drug Delivery

A recent Perspectives article from the laboratory of Biju Parekkadan (Rutgers University, New Jersey, USA) discusses the development of an ex vivo mesenchymal stem cell (MSC) therapeutic adapting principles of classical molecular drug pharmacokinetic and pharmacodynamic framework. Furthermore, Aijaz et al. present examples of general cell engineering techniques that implicitly influence pharmacokinetics/pharmacodynamics by genetically modifying cells to regulate their in vivo duration, biodistribution, and activity. Overall, the authors believe that redefining conventional absorption, distribution, metabolism, and excretion criteria for chemical drugs will help in the pharmacological evaluation of cell therapies. For a riveting read, see STEM CELLS Translational Medicine now!