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Clinical Potential, Challenges, and Perspectives of PSC-HSCs

Patient‐specific hematopoietic stem cells (HSCs) derived from pluripotent stem cells (PSCs) offer a means to treat hematological diseases that currently suffer from a lack of viable therapeutic options. A new review article from the laboratory of Selami Demirci (National Heart Lung and Blood Institutes, National Institutes of Health, Bethesda, Maryland, USA) now highlights current advances regarding the derivation of HSCs from PSCs and discusses the obstacles that must be faced in the development of autologous PSC‐derived HSC transplantation as a therapeutic modality. For a fascinating read, see STEM CELLS Translational Medicine now!