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CIRM Tools and Technologies

The potential of human stem cells to alleviate disease was clear upon the inception of the California Institute for Regenerative Medicine's (CIRM); however, the inaccessibility of relevant living human cells for study has stymied the understanding of human disease. Clinically appropriate manufacturing methods, quality control tools, animal models to evaluate cell therapies, and delivery tools for living products represented significant limiting factors. CIRM's comprehensive vision to build the stem cell therapy field by investing in the development of tools and technologies required to support this emerging discipline has resulted in examples of successfully developed tools, which are now discussed in a Perspective recently published in STEM CELLS Translational Medicine from Lila R. Collins and Kelly A. Shepard (California Institute for Regenerative Medicine, Oakland, California, USA).