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Chromatin Accessibility in Canine Reprogramming

The poor understanding of canine‐specific regulators of cellular reprogramming and pluripotency maintenance has impeded the study of naturally occurring diseases in dogs for translational regenerative medicine research. Now, researchers led by Amir Kol (University of California Davis, Davis, CA, USA) identify differences in the global chromatin landscape that occur during the cellular reprogramming of canine cells and further define candidate barriers that prevent adult canine cells from reprogramming. Questa et al. hope that the genes and loci reported in this new STEM CELLS Translational Medicine study will represent the basis of novel canine‐specific reprogramming protocols in future research efforts and that their research will aid the development of novel and realistic animal models for translational research.