You are hereMarch 19, 2021
Characterizing Photoreceptors in Human iPSC-ROs
As described in a new STEM CELLS Translational Medicine article, researchers led by Tian Xue (University of Science and Technology of China, Hefei, China) recently employed the patch‐clamp technique to systemically describe the progressive maturation of characteristic ionic components in photoreceptor‐like cells from human induced pluripotent stem cell-derived retinal organoid (iPSC-ROs) under both physiological and pathological conditions. The results from Li et al. provide a much‐needed complement to the existing datasets that mainly comprise molecular evidence regarding the in vitro maturation of ROs and demonstrate the use of electrophysiology as a reliable and sensitive indicator for quality control during iPSC-RO differentiation.