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Cell Therapy in Huntington's Disease

Cell therapy is the only approach currently focused on structural and functional restoration in Huntington's disease; however, the lack of benefits demonstrated in the largest fetal cell transplant trial to date cautions against uncontrolled cell therapy treatments. Stem cells should dramatically change the landscape by allowing better control of the donor cell product's quantity and homogeneity. In a new STEM CELLS review article, researchers led by Anne‐Catherine Bachoud‐Lévi (Hôpital Henri Mondor, Créteil, France) propose ways to improve future trials, thereby increasing their chance for success.