You are here

Cell Immaturity and Adipocytic‐potential of hASCs

The expansion of human adipose‐derived stem/stromal cells (hASCs) typically takes place in serum‐containing media, and a recent study led by Louis Casteilla, Frédéric Deschaseaux, and Hélène Leménager (University of Toulouse, France) established that the transforming growth factor β1 present in serum induces the commitment of hASCs toward osteoblast, chondroblast, and vascular smooth muscle cell lineages. The authors of this new STEM CELLS article establish that this commitment impedes the immaturity of hASCs and their adipogenic potential during in vitro cell expansion, including toward beige adipocytes, and so they propose alternative culture methods to expand hASCs with optimal therapeutic interests.