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CD73 on ERCs Mediates Cardiac Allograft Protection

Research has suggested that endometrial regenerative cells (ERCs), mesenchymal‐like stromal cells non-invasively isolated in large numbers from menstrual blood, can promote tissue repair and immunoregulation. A new study from the lab of Hao Wang (Tianjin Medical University, Tianjin, China) has established how the cell-surface expression of ecto‐5′‐nucleotidase (CD73), a key enzyme in purine metabolism, plays a critical role in preventing graft rejection and prolonging cardiac allograft survival by ERCs. Hu et al. believe that their findings will establish a framework for the development of an ERC-based clinical therapy to enhance allograft acceptance. For more, see STEM CELLS Translational Medicine now!