CD166 Interactions and Hematopoietic Function

A previous study out of the labs of Hal E. Broxmeyer and Edward F. Srour (Indiana University School of Medicine, Indianapolis, Indiana, USA) established that CD166 marked murine and human hematopoietic stem cells (HSCs). Now, the same team return with a new STEM CELLS study in which describe how homophilic interactions via CD166 augments the functional potential of these cells. Furthermore, Zhang et al. employ single cell RNAseq to identify pathways activated by the engagement of CD166 on the surface of these cells to enhance hematopoietic function.