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BMDCs Remodel the Postpartum Mouse Uterus

The uterus undergoes significant tissue regeneration in the postpartum period following parturition, where endometrial stem cells may play a key role. Now, a new STEM CELLS study from researchers led by Reshef Tal (Yale School of Medicine, New Haven, CT, USA) reports that bone marrow-derived cells (BMDCs) actively participate in postpartum uterus remodeling in the mouse, undergoing dynamic changes and contributing to various non-immune endometrial cell populations as part of the process of cellular turnover and regeneration. Overall, these observations may have important implications for human uterine physiology and pathological conditions such as postpartum uterine scarring (Image - schematic of the experimental model).