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Biofilm Impairment Via MSC-Secreted Proteases

A new article from researchers led by Gerlinde R. Van de Walle (Cornell University, Ithaca, New York, USA) recently described, for the first time, how the administration of mesenchymal stem cells (MSCs) may represent an effective against means to counteract the activity of bacteria in biofilms, including the antibiotic‐resistant methicillin‐resistant Staphylococcus aureus, via the secretion of active proteases that destabilize biofilms by protein degradation and the associated increased effectiveness of antibiotics. In light of the rise of antibiotic‐resistant bacterial strains as an increasing global health threat, Marx et al. hope that their results will provide the rationale for the implementation of the MSC secretome as a complementary treatment for bacterial infections. For more, see STEM CELLS Translational Medicine now!