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ASCs Restore Bone Regeneration After Infection

Previous research from the lab of Björn Behr (University Hospital Bergmannsheil Bochum, Germany) demonstrated diminished healing capacity following bone infections, mainly due to reduced osteoblastogenesis, increased osteoclastogenesis, and elevated B‐cell activity. In their new STEM CELLS Translational Medicine article, the team evaluated bone regeneration following treatment with adipose‐derived stem cells (ASCs) in an established murine animal model of bone infection. Interestingly, Wagner et al. discovered that ASC treatment prompted the restoration of bone healing via the elevation of osteoblastogenesis and downregulation of both osteoclastogenesis and B‐cell number. Could ASC therapy represent a novel treatment approach?