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Antibacterial Activity of Human MSCs

A new study led by researchers from the lab of Steven Dow (Colorado State University, Fort Collins, Colorado, USA) recently reported the antimicrobial properties of human mesenchymal stem cells (MSCs). Chow et al. have extended the results of previous studies by describing both the direct antimicrobial activity of MSCs and the indirect antimicrobial effects mediated via interaction with host innate immune cells. Excitingly, this new STEM CELLS Translational Medicine study describes in detail how MSC secreted factors augment the antimicrobial activity of conventional antibiotics, including enhanced activity against drug-resistant strains of Staphylococcus aureus. Overall, the authors propose the utility of systemic delivery activated MSCs for the treatment of chronic drug‐resistant infection in human patients.