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Adipose Vascular Niche Regulates Stem Cell Self‐renewal

The maturation and stabilization of blood vessels require the transcription factor lymphoblastic leukemia‐derived sequence 1 (LYL1), and, depending on their permeability properties, said blood vessels can support stem cell quiescence or activation. In a new STEM CELLS study led by Valérie Pinet (University of Montpellier, France), Hussain et al. report that Lyl1‐deficient mice possess porous adipose tissue vascular structures, which suffer from inadequate coverage by pericytes and display pro‐angiogenic properties, thus promoting adipose stem cell differentiation. Overall, this study highlights a role for LYL1 in vascular niche maintenance in adipose tissue.