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Heart Attack: Substitute Muscle thanks to Stem Cells

Würzburg (DE), September 2018 — Myocardial infarction, commonly known as a heart attack, is still one of the main causes of death. According to Germany’s Federal Statistical Office, more than 49,00 people there died of its consequences. And yet the mortality rate after heart attack has greatly decreased over the past decades: Compared to the early 1990s, it more than halved until 2015, according to the German Society of Cardiology (DGK). The reasons for this include better prevention, therapy and rehabilitation.

New 3D-printed Stem Cell Platform Could Help Treat Spinal Cord Injuries

MINNEAPOLIS, MN (US), September 2018 — Engineers and medical researchers at the University of Minnesota have teamed up to create a groundbreaking 3D-printed device that could someday help patients with long-term spinal cord injuries regain some function.

The Alchemy of Healing

LA JOLLA, CA (US), September 2018 — Plastic surgery to treat large cutaneous ulcers, including those seen in people with severe burns, bedsores or chronic diseases such as diabetes, may someday be a thing of the past.

Scientists at the Salk Institute have developed a technique to directly convert the cells in an open wound into new skin cells. The approach relies on reprogramming the cells to a stem cell-like state and could be useful for healing skin damage, countering the effects of aging and helping better understand skin cancer.

Clinical Trial Paves Way for more Widespread Investigation into the Utility of Dental Stem Cells

PHILADELPHIA, PA (US), September 2018 — Nearly half of children suffer some injury to a tooth during childhood. When that trauma affects an immature permanent tooth it can hinder blood supply and root development, resulting in what is essentially a “dead” tooth. 

Until now, the standard of care has entailed a procedure called apexification that encourages further root development, but it does not replace the lost tissue from the injury and, even in a best-case scenario, causes root development to proceed abnormally. 

What’s the Stem Cells Buzz this Week? - Heart-derived Cell Therapies, MSC-Seeded Scaffolds, Amniotic Stem Cells in Corneal Repair, and Profiling Hepatocyte Generation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Urine-derived Stem Cells: An Exciting New Source of Autologous Endothelial Cells?

The differentiation of urine-derived stem cells may represent as a simple and low-cost method to produce endothelial cells for therapeutic purposes

CRISPR-Cas9 Genome Editing of Limbal Stem Cells Generates Faithful Model of Panocular Condition

Using CRISPR-Cas9 genome editing of limbal stem cells, researchers demonstrate the potential utility of PAX6 as a therapeutic tool for aniridia patients

Beat that! – Human ESC-derived Cardiomyocytes Restore Cardiac Function in Monkeys

New findings establish the transplantation of embryonic stem cell-derived cardiomyocytes as an effective means to restore lost cardiac function in monkeys

Properties of Stem Cells That Determine Cell Fate Identified

IRVINE, CA (US), September 2018 — Researchers from the University of California, Irvine have identified intrinsic cell properties that influence the fate of neural stem cells, affecting what type of brain cell they will form: neurons, astrocytes or oligodendrocytes. This discovery could give scientists a new way to predict or control the fate of stem cells, improving their use in transplantation therapies.

Body’s Own ‘Bomb Squad’ can help Protect Against Brain Tumors

BEIJING (PRC), September 2018 — Researchers have discovered how a molecule can help prevent certain types of brain tumors by recognizing and “disarming” harmful proteins that cause them.

Their study in fruit flies, published in eLife, could lead to a potential new treatment approach for brain tumors in future.

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