Recent research aimed at finding a treatment for a common form of blindness could give new meaning to the term “eye teeth.” In a study in mice published in STEM CELLS Translational Medicine, researchers at the University of Pittsburgh show how stem cells harvested from teeth extracted during routine dental procedures can potentially be used to restore sight in those suffering from corneal blindness.
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Stem cells collected from placenta, which is generally discarded after childbirth, show promise as a treatment for heart failure. Found in the latest issue of STEM CELLS Translational Medicine, a new study using mice determined that human-derived adherent cells (PDAC® cells) significantly improved cardiac function when injected into the heart muscle.
Currently, about 6 million people in the United States alone suffer from heart failure, which is when the heart’s pumping power is weaker than normal. Despite intensive medical care, almost 80 percent of people die within eight years of diagnosis, making it the world’s leading cause of death. Heart failure can be the result of coronary artery disease, heart attack and other conditions such as high blood pressure and valve disease.
STEM CELLS Translational Medicine (SCTM) presented Marc H. Dahlke, M.D., Ph.D. its second annual STEM CELLS Translational Medicine Young Investigator Award. The award fosters advancements in the field of stem cells and regenerative medicine by honoring a young researcher who is principle author of an article published in SCTM over the course of a year that is deemed to have the most impact and to push the boundaries of novel and insightful research.
The medical world is excited about the potential that stem cells have demonstrated in aiding the recovery of patients who have suffered a heart attack. Now, a new study appearing in the current issue of STEM CELLS Translational Medicine indicates that stem cells may also benefit those who suffer from hardening of the arteries.
Scientists have for the first time used adult human stem cells to “cure” rats with Parkinson’s disease, a neurodegenerative illness that currently has no cure. The study, published in the current issue of STEM CELLS Translational Medicine, details how a team of researchers working in Germany at the University of Bielefeld (UB) and Dresden University of Technology were able to produce mature neurons using inferior turbinate stem cells (ITSCs).
Shangqin Guo, Ph.D., a scientist at Yale University, is the recipient of the 2014 STEM CELLS Young Investigator Award. The award is presented to a young researcher who serves as principal author of a significant study published in the journal over the past year.
The paper that earned Dr. Guo this recognition is “Dynamic Migration and Cell-Cell Interactions of Early Reprogramming Revealed by High Resolution Time-Lapse Imaging,” published in STEM CELLS’ May 2013 issue. It describes a live cell imaging approach for studying the process of Yamanaka reprogramming at single cell resolution. It also reports on the unexpected dynamic behaviors associated with early reprogramming and explores how such behaviors could compromise conventional experimental designs and interfere with data interpretation.
With more soldiers returning from combat suffering devastating injuries, doctors are turning to a reconstructive surgery that uses tissue transplantation along with immuno-suppression therapy. This approach has had encouraging results; however, rejection of transplanted tissue from an unmatched donor remains a critical complication. A new study found in the latest issue of STEM CELLS Translational Medicine reports that researchers may have found a way around that.
Half of all traumatic injuries to the face result in a loss of teeth and the surrounding tissue and bone that once supported them, which in turn makes these types of injuries very debilitating and difficult to treat. But in a new study published in the latest issue of STEM CELLS Translational Medicine, doctors at the University of Michigan School of Dentistry (UMSoD), Ann Arbor, have found a new way to regenerate a patient’s jawbone through the use of stem cells.
The procedure, done under local anesthesia, significantly speeds up the healing time relative to that of traditional bone grafting while allowing a patient to experience only a minimal amount of pain.
A new way to produce engineered skin not only appears to overcome several pitfalls of current skin grafting technologies, it also speeds up the healing process, reduces scarring and produces hair. The method, outlined in the October issue of STEM CELLS Translational Medicine, could represent a breakthrough for treating deep skin injuries that result from severe burns and chronic wounds.
A deep skin injury completely destroys the skin’s regenerative elements. These wounds heal by contraction, with epithelization (the process by which a new layer of skin is formed) only at the edges. The result is generally reduced joint movement and extensive scarring. In the case of an extensive lesion, healing can sometimes be unsuccessful and the lesion becomes life threatening.
In a recent study published in STEM CELLS Translational Medicine, scientists have found what they believe might be a better way to regrow bone tissue using magnetic nanoparticles coated with targeting proteins that stimulate stem cells to regenerate the bone. They also were able to deliver the cells directly to the injured area, remotely control the nanoparticles to generate mechanical forces and maintain the regeneration process through staged releases of a protein growth factor. These findings might someday have significant impact for anyone suffering from a major bone trauma, disease or defect.