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DURHAM, N.C. (December 2018) Skeletal (mesenchymal) stem cells (MSCs) are being used in an increasing number of clinical trials for their therapeutic benefits in tissue regeneration and fracture healing. However, their poor homing capacity to the injured site presents a major challenge to realizing their full capabilities. A new study recently published in STEM CELLS shows a possible way to overcome that.
Durham, NC (November 19, 2018) – A new study in STEM CELLS Translational Medicine indicates mesenchymal stem cells (MSCs) are a safe and innovative option to heal normal tissue following radiotherapy. Alain Chapel, Ph.D., and Annette Larsen, DVM, Ph.D., of the Institut National de la Santé et de la Recherche Médicale (INSERM) in France led the team that conducted this research.
More than 14 million new cases of cancer are diagnosed globally each year, according to the National Institutes of Health. Of those, half could benefit from radiation therapy. However, radiotherapy can cause substantial damage to a patient’s normal tissue. Mesenchymal stem cells (MSCs) have been used to help alleviate this damage, but their potential to lead to residual tumor cells is worrisome.
DURHAM, N.C. NOVEMBER (2018) - A new study released today in STEM CELLS Translational Medicine demonstrates how a biodegradable hydrogel sponge seeded with olfactory stem cells (OSCs) greatly accelerated recovery from facial palsy in mice. The technique, developed by a team of researchers at Nagoya City University, Japan, shows potential for treating humans suffering from this condition — a frequent result of temporal bone fractures — as well as from other similar trauma or diseases such as Bell’s palsy or Ramsay Hunt syndrome, a painful byproduct of shingles.
Durham, NC (November 5, 2018) – A study recently published in STEM CELLS Translational Medicine (SCTM) describes a new cell therapy that shows promise in treating cirrhosis of the liver. The treatment, combination of mesenchymal stem cells and induced bone marrow-derived macrophages, reduced fibrosis and promoted regeneration of cirrhosis-damaged liver in tests on mice.
Durham, NC (October 31, 2018)– A study released today in STEM CELLS moves scientists a step closer to finding how to help the body regenerate joint cartilage ravaged by disease. Their work reveals a new method to quickly and efficiently produce virtually unlimited numbers of chondrocytes, the cells that form cartilage, from human skin cells converted to induced pluripotent stem cells (iPSCs). For the 54 million Americans suffering from arthritis – the nation’s Number One disability – this could be great news.
DURHAM, N.C. (PRWEB) OCTOBER 08, 2018
A new study published in STEM CELLS Translational Medicine shows that the energy metabolism of human mesenchymal stem cells (hMSCs) can be targeted to increase their ability to enhance tissue regeneration. The study offers a strategy that has immediate translational potential for improving hMSCs’ therapeutic success.
hMSCs have gained significant interest as an “off-the-shelf” product for cell therapy in various types of diseases. Recent findings suggest that instead of replacing damaged cells through differentiation, as initially thought, hMSCs promote tissue regeneration by coordinating multiple components of the host immune system via the release of immunomodulatory factors. Therefore, understanding the mechanism underpinning hMSC immune polarization and secretory function is critical to enhancing their therapeutic outcome.
DURHAM, NC — A study recently published in STEM CELLS suggests unrestricted somatic stem cells (USSCs) derived from human cord blood can ease fibrosis and inflammation in a painful type of skin disorder called recessive dystrophic epidermolysis bullosa (RDEB). The stems cells also can potentially prevent malignant tumors, a frequent side effect of RDEB, from forming.
Durham, NC, September (2018) – A new study published in STEM CELLS Translational Medicine details a novel stem cell treatment with the potential to restore sight after a serious chemical burn to the eye.
DURHAM, N.C. (SEPTEMBER, 2018)
A team of researchers developed a biocompatible scaffold seeded with molecule-releasing stem cells that, when implanted in mice with a rare but deadly bone disease called autosomal recessive osteopetrosis (ARO), showed potential to help these animals. The findings, recently published in STEM CELLS Translational Medicine (SCTM), might someday yield a treatment for humans afflicted by the same devastating condition.
DURHAM, N.C. August, 2018
A new study recently published in STEM CELLS Translational Medicine demonstrates the long-term safety of laboratory-expanded endothelial progenitor cells for treating ischemic stroke. This could be good news for the 15 million people who, according to to the World Stroke Organization, suffer from this dangerous condition each year.
The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications.
