Prior to the study, which is published in the current edition of PLoS ONE, hematopoietic stem cells were thought to have no other option when they went into quiescence and that it was brought on by a lack of nutrients or stimulation.
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Coverage of the latest news and updates from the field of stem cells and regenerative medicine.
Osteonecrosis occurs when the patient's bone tissue dies after a loss of blood supply to the area. If the bone involved is near a joint, it can cause the joint surface to collapse. In most cases, the disease first attacks people in their late 30s and 40s.
The U.S. National Heart, Lung and Blood Institute reports that in the United States alone, about 5.8 million people suffer from heart failure.
Their work, published May 4 in Cell Stem Cell, sets the stage for future human clinical trials.
"Despite the huge potential of stem cells for therapeutic use, very few people have actually investigated their basic biology," said study senior researcher Mohanish Deshmukh, Ph.D., of the University of North Carolina at Chapel Hill (US).
Scientists at Cincinnati Children's Hospital Medical Center (US) and the Ulm University Medicine in Germany reported their findings online May 3 in Cell Stem Cell.
The facility will produce GIBCO® cell culture products used for biological drug research, development and production. The company expects to break ground at the site in 2013 and to ship product from the facility beginning in 2014.
The funding is expected to advance the therapeutic candidate through the submission of an IND application to the U.S. Food and Drug Administration.
Such damage might foreshadow later problems, including cancer.
The line, known as UM11-1PGD, was derived from a cluster of about 30 cells removed from a donated five-day-old embryo that carried the gene defect responsible for Charcot-Marie-Tooth (CMT) disease, a hereditary neurological disorder characterized by a slowly progressive degeneration of the muscle