These findings provide a platform for future development of patient-specific stem/progenitor cells and more differentiated blood products for cell-replacement therapy.
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Coverage of the latest news and updates from the field of stem cells and regenerative medicine.
A clinical hold is an order issued by the FDA to delay a proposed clinical investigation or to suspend an ongoing investigation. Once the applicant has submitted a complete response to the clinical hold, the FDA must evaluate the response and decide whether to lift the hold.
“We found that not only can we make adult cells, but also placenta,” said DanStem’s Josh Brickman, PhD., who led the study. “In fact we got precursors of placenta, yolk sac as well as embryo, from just one cell.”
Habib Zaghouani, Ph.D., led the research team at the University of Missouri School of Medicine. "We discovered that Type 1 diabetes destroys not only insulin-producing cells but also blood vessels that support them," he said.
All the patients in the trial suffered a stroke between six months and five years before they received the treatment, in which stem cells were injected into the damaged area of the brain.
“Ultimately, we want to identify stem cells that can be used as a resource to stimulate tooth renewal in adult humans who have lost teeth. But, to do that, we must first understand how they renew in other animals and why they stop in people,” Dr. Chuong explained.
“To do the best science you need to have the very best scientists, and this award means that CIRM has attracted another six of the top researchers in stem cells and regenerative medicine in the world to California,” says Alan Trounson, Ph.D., president of the stem cell agency.
The problems were initially brought to light on Pubpeer, a website for anonymous comments about published papers.
The technique used by Dr. Mitalipov, Paula Amato, M.D., and their colleagues in OHSU’s Department of Obstetrics & Gynecology, is a variation of a commonly used method called somatic cell nuclear transfer, or SCNT.
“There is a widely held misconception that the adult nervous system is static or fixed, and has a limited capacity for repair and regeneration,” said Dwight Bergles, Ph.D., professor of neuroscience and otolaryngology at the Johns Hopkins University School of Medicine.