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First Treatment for Pain Using Human Stem Cells a Success

SYDNEY (AU), January 2020 — Researchers at the University of Sydney have used human stem cells to make pain-killing neurons that provide lasting relief in mice, without side effects, in a single treatment.

The next step is to perform extensive safety tests in rodents and pigs, and then move to human patients suffering chronic pain within the next five years.

If the tests are successful in humans, it could be a major breakthrough in the development of new non-opioid, non-addictive pain management strategies for patients, the researchers said.

"We are already moving towards testing in humans," said Greg Neely, Ph.D., associate professor at the School of Life and Environmental Sciences.

"Nerve injury can lead to devastating neuropathic pain and for the majority of patients there are no effective therapies. This breakthrough means for some of these patients, we could make pain-killing transplants from their own cells, and the cells can then reverse the underlying cause of pain."

Published recently in Pain, the team used human induced pluripotent stem cells (iPSC) derived from bone marrow to make pain-killing cells in the lab, then put them into the spinal cord of mice with serious neuropathic pain.

"Remarkably, the stem cell neurons promoted lasting pain relief without side effects," said co-senior author Leslie Caron, Ph.D. "It means transplant therapy could be an effective and long-lasting treatment for neuropathic pain. It is very exciting."

John Manion, a Ph.D. student and lead author of the paper said, "Because we can pick where we put our pain-killing neurons, we can target only the parts of the body that are in pain. This means our approach can have fewer side effects."

The stem cells used were derived from adult blood samples.

Learn more:
https://www.eurekalert.org/pub_releases/2020-01/uos-ftf012320.php
DOI: 10.1097/j.pain.0000000000001733