Researchers report on the administration of sibling umbilical cord blood infusions in fifteen children with cerebral palsy
You are here
Summaries of the most recent articles published in STEM CELLS and STEM CELLS Translational Medicine.
A new review discusses the emerging role of mitochondria in neural progenitor cells and the regulation of cell fate decisions during neurogenesis
A new study reports the safety of autologous administration of bone marrow-derived mesenchymal stem cells in patients with type 2 diabetes mellitus
Researchers report StemCellQC as a label-free video bioinformatics analysis tool for evaluating pluripotent stem cell morphology, quality, and dynamics during in vitro culture
Researchers probe the function of Zbtb46 in embryonic stem cell-derived blood cell progenitors using chemically inducible transgenic cell lines
A robust and reproducible flow cytometry strategy associated with the alveolosphere assay can characterize resident mesenchymal cells in the lung
Researchers report the decoding of the secretome of clinical trial-biobanked cardiopoietic cells and link innate secretome traits with therapeutic outcomes
Researchers report that adenosine A2A receptor activation enhances postnatal and adult hippocampal neurogenesis
A recent STEM CELLS review article from researchers led by Alessandro Prigione (Heinrich Heine University (HHU), Düsseldorf, Germany) discusses the emerging role of mitochondria in neural progenitor cells and the regulation of cell fate decisions during neurogenesis. Brunetti et al. believe that elucidating the importance of mitochondria in neurogenesis might be instrumental in identifying interventional targets for mitochondrial diseases, a group of rare, incurable disorders that cause neurological and neurodevelopmental defects.
New research from the labs of Liem Thanh Nguyen and Duc M. Hoang (Vinmec Healthcare System, Hanoi, Vietnam) has revealed the safety of autologous administration of bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with type 2 diabetes mellitus (T2DM) and a lack of significant difference in efficacy between intravenous and dorsal pancreatic artery infusion. In their recent STEM CELLS Translational Medicine article, Nguyen et al. demonstrated that MSC administration leads to a short-term reduction in hemoglobin A1c and fasting blood glucose levels in patients with T2DM history <10 years and body mass index <23; overall, phenotypic analysis provisionally links treatment effectiveness to the duration of T2DM. Thus, this study suggests autologous administration of BM-MSCs to treat T2DM in patients with T2DM duration <10 years and no obesity.
Researchers led by Prue Talbot (University of California, Riverside, CA, USA) recently reported StemCellQC, a label-free video bioinformatics analysis tool for evaluating pluripotent stem cell (PSC) morphology, quality, and dynamics during in vitro culture. As reported in their recent STEM CELLS Translational Medicine article, Lin et al. used StemCellQC to quantitatively compared the morphology, growth, motility, and death of PSCs grown on different matrices, in different media, in conditions of stress, and the presence of an environmental toxicant. In addition, the authors report that StemCellQC can be applied to problems in basic, toxicological, translational, and clinical laboratories working with PSCs and used to optimize in vitro culture conditions and monitor colony quality to ensure safe translation of technology to humans.
While the transcription factor Zbtb46 is a hallmark of dendritic cells, the exact function of this protein remains poorly characterized. In a new STEM CELLS article, researchers led by Istvan Szatmari (University of Debrecen, Hungary) probed the function of Zbtb46 in embryonic stem cell (ESC)-derived blood cell progenitors using chemically inducible transgenic cell lines. Boto et al. discovered that the forced expression of Zbtb46 profoundly suppressed myeloid blood cell development but enhanced erythroid colony formation and adult hemoglobin expression. These findings suggest that Zbtb46 can function as a molecular regulator to redirect early blood cell differentiation.
The mesenchyme comprises a range of subpopulations that remain uncharacterized. These include the resident mesenchymal cells (rMC-Sca1+) reported to support epithelial stem cell self-renewal. In a new STEM CELLS article, researchers led by Saverio Bellusci (Justus-Liebig University Giessen, Germany) and Jin San Zhang (The First Affiliated Hospital of Wenzhou Medical University, China) report a robust and reproducible flow cytometry strategy associated with the alveolosphere assay to characterize resident mesenchymal cells in the lung. Furthermore, Taghizadeh et al. indicate that rMC-Sca1+ cells support AT2 stem cell self-renewal and differentiation and break this population down further into two important distinct populations.
In a new STEM CELLS Translational Medicine article, researchers led by Andre Terzic (Mayo Clinic, Rochester, MN, USA) report the decoding of the secretome of clinical trial-biobanked cardiopoietic cells. Arrell et al. reported the echoing of the mined (cardiomyo)vasculogenic systems signature in the response of cell recipients demonstrating disease rescue. Overall, this clinomics study links innate secretome traits with therapeutic outcomes.
In a recent STEM CELLS article, researchers led by Sara Xapelli (Universidade de Lisboa, Lisbon, Portugal) report that adenosine A2A receptor (A2AR) activation enhances postnatal and adult hippocampal neurogenesis. Ribeiro et al. demonstrated that this was made possible through the increased self-renewal capacity of Type 1 and Type 2 cells and neuronal committed cell protection, differentiation, and branching. Furthermore, A2AR activation promoted the secretion of brain-derived neurotrophic factor, which was essential for A2AR activity, and BDNF-mediated neuronal differentiation but not self-renewal.
Bone homeostasis depends largely on the number and function of osteoblasts; however, bone marrow mesenchymal stem cells (MSCs) give rise to both osteoblasts and adipocytes, and a competitive relationship exists between adipogenesis and osteogenesis. In a recent STEM CELLS article, researchers led by Baoli Wang (Tianjin Medical University, Tianjin, China) identify a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-Wnt/β-catenin regulatory axis that governs the cell fate of MSCs by favoring osteoblast differentiation and blocking adipocyte formation. Wu et al. report that HMGA1, as a downstream target of NFIX, functions by transcriptionally regulating low-density lipoprotein receptor-related protein 5 (LRP5) expression and thereafter activating canonical Wnt signaling. Overall, this exciting new study suggests NFIX/HMGA1 as a novel therapeutic target for treating metabolic bone disorders such as osteoporosis.
A new STEM CELLS Translational Medicine study from researchers led by Shuying Yang (University of Pennsylvania, Philadelphia, PA, USA) aimed to explore the basic mechanisms of spine development by studying Col2+ progenitor cells. Li et al. discovered that embryonic Col2+ cells contribute primarily to spinal cord development and that Col2+ progenitors participate in intervertebral disc repair and regeneration.
A new STEM CELLS article from researchers led by Bronwen Connor (the University of Auckland, New Zealand) describes the first reported generation of directly reprogrammed neural precursor cells and DARPP32+ neurons from adult-onset Huntington's disease patient samples. In addition, Monk et al. observed the formation of ubiquitinated polyglutamine aggregates and impaired neuronal maturation in reprogrammed Huntington's disease neurons, and noted a correlation between BDNF expression and Huntington's disease severity. Overall, this exciting study represents a novel platform to screen for new targets for the treatment of Huntington's disease.