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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

January 21, 2013 |

"Efficient Lentiviral Transduction of Human Mesenchymal Stem Cells That Preserves Proliferation and Differentiation Capabilities"

Mesenchymal stem cells (MSCs) are important in regenerative medicine to structurally repair injured tissues, such as bone (Kadiyala et al.) and cartilage (Solchaga et al.), and restore their lost functions. This usefulness can be expanded...

January 21, 2013 | Neural Stem Cells

"Embryonic Stem Cell-Derived Neural Stem Cells Fuse with Microglia and Mature Neurons"

Recent studies into the transplantation of neural stem cells (NSCs) in animal models have suggested that this may represent a novel strategy in combating loss of function in human brain disorders. However, the proposed mechanisms by which this is accomplished are many; neuron...

January 21, 2013 | Mesenchymal Stem Cells

"Intranasal Delivery of Neural Stem/Progenitor Cells: A Non-invasive Passage to Target Intracerebral Glioma"

The use of neural stem cells and neural progenitor cells (NSPCs) for various central nervous system (CNS) diseases is an emerging therapy which benefits from these cells restorative potential and their ability to preferentially migrate to sites of disease and...

January 21, 2013 | Mesenchymal Stem Cells

Original article from STEM CELLS

"Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential"

Autologous mesenchymal stem cells (MSCs) are an attractive source of cells for use in a regenerative capacity, however several problems have arisen which may limit their extensive...

January 21, 2013 | Pluripotent Stem Cells

"Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System"

The regulation of pluripotency has been assessed on many different levels; transcription factor networks, epigenetic regulation and miRNA analysis. However, the role of posttranslational modifications in embryonic stem cell (ESC) pluripotency and differentiation has not been fully...

January 21, 2013 | Pluripotent Stem Cells

"Towards germline gene therapy of inherited mitochondrial diseases"

Human disease caused by mutations in mitochondrial DNA (mtDNA) is thought to affect between 1000 and 4000 children born in the US every year (Haas et al. and Schaefer et al.) although some estimates have this at a much higher level (Elliott et al.). While there are no cures for mitochondrial disorders...

December 10, 2012 | Mesenchymal Stem Cells

Original article from STEM CELLS

“Injury-Activated Transforming Growth Factor β Controls Mobilization of Mesenchymal Stem Cells for Tissue Remodeling”

Adult stem/progenitor cells are able to differentiate into many cell types and can also be recruited to a site of injury where they either repair the injured tissue or contribute to tissue...

December 10, 2012 | Haploid Stem Cells

Recent successes in establishing haploid embryonic stem cells in mice (Elling et al and Leeb and Wutz) have raised the possibility of using these cells in genetic studies by producing models of recessive traits, while also...

December 10, 2012 | Pluripotent Stem Cells

Recent studies have begun to describe means of directing the differentiation of male and female germ cells from embryonic stem cells (ESCs) towards sperm and oocytes. The group of Mitinori Saitou at Kyoto University, Japan have previously described the production of primordial germ cell–like cells (PGCLCs) from male mouse ESCs and induced pluripotent stem cells (iPSCs) with which allow for...

December 10, 2012 | Pluripotent Stem Cells

While the overexpression of specific transcription factors in embryonic stem cells (ESCs) can allowed the production of specific cell types such as haematopoietic stem/progenitor cells, adipocytes and neural progenitors, our ability to form functional artificial organs from these cells is still limited (Eiraku et al, Eiraku and Sasai, and Suga et al). Now, in a study...

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