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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

October 22, 2012 | Pluripotent Stem Cells

Original article from STEM CELLS

“Regulation and Expression of the ATP-Binding Cassette Transporter ABCG2 in Human Embryonic Stem Cells”

ATP-binding cassette sub-family G member 2 (ABCG2) is known to function as a multidrug efflux pump and plays a role in resistance to chemotherapeutic agents in cancer cells. While it has been implicated...

October 22, 2012 | Ependymal Stem Cells

Original article from STEM CELLS

“FM19G11 Favors Spinal Cord Injury Regeneration and Stem Cell Self-Renewal by Mitochondrial Uncoupling and Glucose Metabolism Induction”

Activation of resident adult stem/progenitor cells for the treatment of some disease/injury states is often seen as a viable alternative to the transplantation of...

October 22, 2012 | Skin Stem Cells

Original article from STEM CELLS

“Skin-derived Precursors as a Source of Progenitors for Cutaneous Nerve Regeneration”

Studies have taught us that while peripheral cutaneous nerves have an amazing regenerative capability in response to damage (Navarro et al), numerous human diseases are associated with incomplete nerve...

October 12, 2012 | Adipose Stem Cells

Original article from STEM CELLS Translational Medicine

“An Abundant Perivascular Source of Stem Cells for Bone Tissue Engineering”

The isolation of mesenchymal stem cell (MSC)-like cells for bone formation/regeneration currently relies on their ability to adhere to culture plates and their extended growth in vitro, which...

October 12, 2012 | Pluripotent Stem Cells

Original article from STEM CELLS Translational Medicine

“Variability in the Generation of Induced Pluripotent Stem Cells - Importance for Disease Modeling”

One of the most interesting uses of induced pluripotent stem cells (iPSCs), alongside potential immunologically matched cell replacement therapy, is the modelling of complex human diseases (Vitale...

October 12, 2012 | Neural Stem Cells

Original article from STEM CELLS Translational Medicine

“Neural Stem Cell Grafting Counteracts Hippocampal Injury-Mediated Impairments in Mood, Memory, and Neurogenesis”

Injury to the hippocampus, an organ vital for cognitive and mood function (Deng et al and Samuels and Hen), is understood to lead to increased neurogenesis from...

October 8, 2012 |

“Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–Like Cells in Mice”

A report from a team of researchers at Kyoto University published online in Science, and reported widely (see further reading), has demonstrated the ability of primordial germ cell-like cells (PGCLCs) derived from mouse embryonic stem cells (mESCs) and induced pluripotent stem cells (iPSCs) to produce...

October 8, 2012 | Pluripotent Stem Cells

“Epigenetic stability, adaptability, and reversibility in human embryonic stem cells”

Human embryonic stem cells (hESCs) are known to adapt during extended periods of ­­in vitro culture, a process potentially detrimental to later differentiation ability. However, the mode of initiation of transcriptional changes and the potential for reversibility of adaptation mediated by culture...

October 8, 2012 | Pluripotent Stem Cells

“A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts”

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is known to involve the genome-wide remodelling of chromatin and it has been suggested that small molecules which can affect the chromatin landscape could be used to reactivate the endogenous pluripotency...

October 8, 2012 | Pluripotent Stem Cells

“Mouse ooplasm confers context-specific reprogramming capacity”

The mammalian oocyte mediates one of the largest periods of DNA methylation dynamics; global demethylation of the paternal genome, a process required for the establish­ment of totipotency and developmental competence (Reik et al 2011). Somatic cell nuclear transfer (SCNT) attempts to recapitulate this artificially...