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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

March 19, 2013 | Germ Cells

“The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation”

Research into embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) has allowed a greater understanding of the development and differentiation of specific cellular lineages and the molecular...

March 12, 2013 | Adult Stem Cells

"A new type of stem cell found"

Researchers at the University of California in San Francisco have identified a potentially new type of stem cell, which they have called endogenous pluripotent stem cells (ePS cells). This rare population of stem cells found in healthy adult human breast tissue express OCT3/4, SOX2, and NANOG at levels similar to human embryonic stem...

March 12, 2013 |

"First iPSC clinical trials to take place in Japan"

Since their conception in 2006,1 induced pluripotent stem cells (iPSCs) have been heralded as a powerful tool for the study of development and disease and a valuable potential resource of transplantable tissue for regenerative medicine. With seemingly identical developmental potential to human embryonic stem cells (...

March 11, 2013 | Haematopoetic Stem Cells

Original article from STEM CELLS

"Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery After Radiation Injury"

Modulation of the bone marrow microenvironment to allow the expansion and engraftment of hematopoietic stem and progenitor cells (HSPCs) following transplantation has shown some...

March 11, 2013 |

Original article from STEM CELLS

"Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration"

Macrophages (MPs), one of the main agents of innate immunity, have been shown to enhance tissue damage (Gray et al and Jung et al), but can also aid tissue homeostasis and repair, as...

February 15, 2013 | Pluripotent Stem Cells

"Modeling and Rescue of the Vascular Phenotype of Williams-Beuren Syndrome in Patient Induced Pluripotent Stem Cells"

Williams-Beuren syndrome (WBS) is associated with abnormal arterial narrowing caused by a hemizygous microdeletion involving 26–28 genes, including Elastin (ELN), affecting 1:10,000 individuals. Cardiovascular complications are the major cause of death...

February 15, 2013 | Mesenchymal Stem Cells

"Injection of Vessel-Derived Stem Cells Prevents Dilated Cardiomyopathy and Promotes Angiogenesis and Endogenous Cardiac Stem Cell Proliferation in mdx/utrn−/− but Not Aged mdx Mouse Models for Duchenne Muscular Dystrophy"

Duchenne muscular dystrophy (DMD) is an X-linked muscle wasting disease affecting approximately 1/3,500 male live births (Emery) and results from...

February 15, 2013 |

"Human Mesenchymal Stem Cell Grafts Enhance Normal and Impaired Wound Healing by Recruiting Existing Endogenous Tissue Stem-Progenitor Cells"

Mesenchymal stem cells (MSCs) are an attractive source for many cell-mediated therapies due to their ability to expand well in culture and their differentiation abilities (Chen and Tuan, and Chen et al). However, the lack of...

February 15, 2013 | Pluripotent Stem Cells

"Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome"

Each passing month brings more in depth analysis of the mechanisms lying behind the induction of pluripotency from somatic cells. We currently know that only a small percentage of cells become reprogrammed into induced pluripotent stem cells (iPSCs) (Plath and...

February 15, 2013 | Pluripotent Stem Cells

"SMAD7 Directly Converts Human Embryonic Stem Cells to Telencephalic Fate by a Default Mechanism"

Neural induction (Spermann and Mangold) is generally understood to be controlled through the inhibition of transforming growth factor (TGF) β signaling. Signalling is controlled through ligand-dependent dimerization and activation of type I and type II serine-threonine...