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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

April 1, 2013 | Pluripotent Stem Cells

“Comparative Analysis of Targeted Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) and Human Embryonic Stem Cells Reveals Variability Associated With Incomplete Transgene Silencing in Retrovirally Derived hiPSC Lines”

From Stem Cells Translational Medicine

Multiple studies have been published on the comparison of human...

April 1, 2013 | Neural Stem Cells

“Neural Progenitors Derived From Human Induced Pluripotent Stem Cells Survive and Differentiate Upon Transplantation into a Rat Model of Amyotrophic Lateral Sclerosis”

From Stem Cells Translational Medicine

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which ultimately leads to death by failure...

April 1, 2013 | Pluripotent Stem Cells

“Modeling Human Protein Aggregation Cardiomyopathy Using Murine Induced Pluripotent Stem Cells”

From Stem Cells Translational Medicine

Mutations in the heat shock protein αB-crystallin (CryAB) are linked to skeletal and cardiac myopathies (Rajasekaran et al, Vicart et al and Wang et al) with one specific mutation (...

April 1, 2013 | Pluripotent Stem Cells

“Derivation of Multiple Cranial Tissues and Isolation of Lens Epithelium-Like Cells From Human Embryonic Stem Cells”

From Stem Cells Translational Medicine

Cells from the neural plate border (NPB) are known to give rise to neural crest cell (NC) and cranial placode (CP) progenitors (Streit) aided by signalling from the neural plate,...

March 27, 2013 | Cancer Stem Cells

Original article from STEM CELLS

"Preventive Cancer Stem Cell-Based Vaccination Reduces Liver Metastasis Development in a Rat Colon Carcinoma Syngeneic Model"

Cancer stem cells (CSCs) represent a minor population of self-renewing cells that fuel tumour growth and have recently been identified in solid tumors, including those in the...

March 27, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"An Efficient Nonviral Method to Generate Integration-Free Human-Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells"

Induced pluripotent stem cell (iPSCs) production is a labour intensive process which has yet to identify a preferred cell source or protocol for their induction...

March 27, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology"

Patients with Down syndrome (DS), the most frequent cause of human congenital mental retardation (Parker et al), exhibit severe aberrations in their nervous system (see...

March 19, 2013 | Pluripotent Stem Cells

March 2013 - Researchers at the cancer and stem cell development company Minerva Biotechnologies have announced that a newly discovered natural human growth factor, called NM23-H1, can maintain the pluripotency of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSC) in a culture system that is free of feeder cells, conditioned...

March 19, 2013 | Cancer Stem Cells

“Dclk1 distinguishes between tumor and normal stem cells in the intestine”

The study of tumour stem cells (TSCs) has been hindered by the lack of selective markers which can differentiate between normal stem cells (NSCs) and TSCs. In the intestine, many markers of NSCs and TSCs are shared (Delarba et al, O’Brien et al, Zhu et al and Todaro...

March 19, 2013 | Pluripotent Stem Cells

 “Genetic Correction of Human Induced Pluripotent Stem Cells from Patients with Spinal Muscular Atrophy”

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder which is associated with the selective degeneration of spinal cord motor neurons (Crawford and Pardo). It is understood to be caused by a genetic defect in the...

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