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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

May 3, 2013 | Pluripotent Stem Cells

“Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28”

Embryonic stem cells (ESCs) have been shown to contain relatively high levels of ‘damaged’ proteins such as carbonylated proteins (Hernebring et al 2006), which are eliminated upon differentiation and are also observed to accumulate in aging...

May 3, 2013 | Pluripotent Stem Cells

“Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aß and Differential Drug Responsiveness”

Oligomerisation of amyloid-β peptide (Aβ) leading to amyloid plaques in the brain is thought to play a role in the pathogenesis of Alzheimer’s disease (AD) in humans (Kuo et al,  Noguchi et al...

May 3, 2013 | Pluripotent Stem Cells

“An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells”

Induced pluripotent stem cell (iPSC)-derived myogenic progenitors are considered a possible treatment for Duchenne muscular dystrophy (DMD), a progressive and incurable neuromuscular disease. This would involve the ex vivo correction of the...

May 3, 2013 | Pancreatic Stem Cells

The exciting discovery of a new, naturally occurring hormone that induces dramatic reproduction of insulin-producing beta pancreatic cells, published in the April edition of Cell by Harvard’s Douglas Melton and Peng Yi,1 has the potential to revolutionise the way that Type 2 diabetes is treated.

May 2, 2013 | Pluripotent Stem Cells

“Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs”

Modelling genetic disorders using induced pluripotent stem cells (iPSCs) is an emerging tool for researchers;  however cells derived from iPSCs, such as cardiomyocytes (CMs), have not yet been qualified as useful models of adult disease phenotypes. Now researchers from the...

May 2, 2013 | Pluripotent Stem Cells

“Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells” and “Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation” 

Antigen-specific T cells have been proposed as a potentially important therapeutic cell type in the prevention or treatment of cancer or viral...

May 2, 2013 | Pluripotent Stem Cells

“Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination”

Human embryonic stem cells (hESCs) (Hu et al, Izrael et al and Keirstead et al) and foetal and adult human brain tissue (Dietrich et al, Roy et al ...

April 18, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"Decrease in Abundance of Apurinic-Apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture-Adapted Human Embryonic Stem Cells"

Unfortunately, one of the characteristics of long term cultivation of human embryonic stem cells (hESCs)...

April 18, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"An Oct4-pRb Axis, Controlled by MiR-335, Integrates Stem Cell Self-Renewal and Cell Cycle Control"

The Retinoblastoma (pRb) protein has been linked to the regulation of the self-renewal capabilities of mouse embryonic stem cells (mESCs) (Dannenberg et al and Kim et al) and also...

April 18, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells"

The mitochondrial genome (mtDNA) encodes some of the key subunits of the electron transfer chain (ETC), essential for the generation of ATP through oxidative phosphorylation....

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