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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

May 2, 2013 | Pluripotent Stem Cells

“Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells” and “Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation” 

Antigen-specific T cells have been proposed as a potentially important therapeutic cell type in the prevention or treatment of cancer or viral...

May 2, 2013 | Pluripotent Stem Cells

“Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination”

Human embryonic stem cells (hESCs) (Hu et al, Izrael et al and Keirstead et al) and foetal and adult human brain tissue (Dietrich et al, Roy et al ...

April 18, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"Decrease in Abundance of Apurinic-Apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture-Adapted Human Embryonic Stem Cells"

Unfortunately, one of the characteristics of long term cultivation of human embryonic stem cells (hESCs)...

April 18, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"An Oct4-pRb Axis, Controlled by MiR-335, Integrates Stem Cell Self-Renewal and Cell Cycle Control"

The Retinoblastoma (pRb) protein has been linked to the regulation of the self-renewal capabilities of mouse embryonic stem cells (mESCs) (Dannenberg et al and Kim et al) and also...

April 18, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

"Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells"

The mitochondrial genome (mtDNA) encodes some of the key subunits of the electron transfer chain (ETC), essential for the generation of ATP through oxidative phosphorylation....

April 1, 2013 | Mesenchymal Stem Cells

 “Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation”

From Stem Cells Translational Medicine

New means of improving for long-term survival of transplanted kidneys have been searched for unsuccessfully (Pascual et al), but...

April 1, 2013 | Pluripotent Stem Cells

 “Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models”

From Stem Cells Translational Medicine

Notch signaling, which plays a role in a variety of developmental processes by controlling cell fate decisions through the regulation of interactions...

April 1, 2013 | Pluripotent Stem Cells

“Comparative Analysis of Targeted Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) and Human Embryonic Stem Cells Reveals Variability Associated With Incomplete Transgene Silencing in Retrovirally Derived hiPSC Lines”

From Stem Cells Translational Medicine

Multiple studies have been published on the comparison of human...

April 1, 2013 | Neural Stem Cells

“Neural Progenitors Derived From Human Induced Pluripotent Stem Cells Survive and Differentiate Upon Transplantation into a Rat Model of Amyotrophic Lateral Sclerosis”

From Stem Cells Translational Medicine

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which ultimately leads to death by failure...

April 1, 2013 | Pluripotent Stem Cells

“Modeling Human Protein Aggregation Cardiomyopathy Using Murine Induced Pluripotent Stem Cells”

From Stem Cells Translational Medicine

Mutations in the heat shock protein αB-crystallin (CryAB) are linked to skeletal and cardiac myopathies (Rajasekaran et al, Vicart et al and Wang et al) with one specific mutation (...

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