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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

June 7, 2013 | Pluripotent Stem Cells

"Short Telomeres in ESCs Lead to Unstable Differentiation"

The ability to maintain telomere length is one of the many attributes of embryonic stem cells (ESCs) (Huang et al). Comprising of reverse transcriptase (Tert) and RNA template (Terc), telomerase mediates the addition of new telomeric DNA to the end of chromosomes which is required for ESC function (...

June 7, 2013 |

"Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits"

Functionality of basal forebrain cholinergic neurons (BFCNs) and γ-aminobutyric acid (GABA) interneurons, derived from medial ganglionic eminence (MGE) (Sussel et al), are linked to learning and memory, and the ability to produce human MGE-...

June 7, 2013 | Pluripotent Stem Cells

"A Simple and Scalable Process for the Differentiation of Retinal Pigment Epithelium From Human Pluripotent Stem Cells" and "Rapid and Efficient Directed Differentiation of Human Pluripotent Stem Cells Into Retinal Pigmented Epithelium"

The high prevalence of blindness caused by age-related macular degeneration (AMD) (Gehrs et al), due to damaged or...

June 7, 2013 | Mesenchymal Stem Cells

"Comparison of Drug and Cell-Based Delivery: Engineered Adult Mesenchymal Stem Cells Expressing Soluble Tumor Necrosis Factor Receptor II Prevent Arthritis in Mouse and Rat Animal Models"

Tumor necrosis factor-α (TNFα) is a cytokine that mediates normal homeostatic mammalian processes (Schaible et al and Wajant et al) but has been linked to the systemic...

June 7, 2013 | Haematopoetic Stem Cells

"Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells"

The group of Richard A. Lerner at The Scripps Research Institute, La Jolla, CA have previously described a means of expressing antibodies through lentiviral infection of cells and studying how the cells are affected in an autocrine manner (Zhang et al)...

June 7, 2013 | Pluripotent Stem Cells

"A simple tool to improve pluripotent stem cell differentiation"

Studies of pluripotent cells types have suggested that cell lines differ in their differentiation propensities (Bock et al and Osafune et al), meaning that only certain lines can be used to generate certain cells/tissues. However this contention has now been challenged by researchers from the...

May 28, 2013 | Neural Stem Cells

Original article from STEM CELLS TRANSLATIONAL MEDICINE

 “Safety of epicentre versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy”

The ability to successfully replace lost or dysfunctional neurons of the central nervous system (CNS) by transplanting ...

May 21, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

 “Clonal Isolation of an Intermediate Pluripotent Stem Cell State”

Embryonic stem cells (ESCs) established from preimplantation embryos, and epiblast stem cells (EpiSCs) established from postimplantation embryos, represent two different cell types which have the ability to self-...

May 21, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

“Dynamic Migration and Cell-Cell Interactions of Early Reprogramming Revealed by High-Resolution Time-Lapse Imaging”

The creation of induced pluripotent stem cells (iPSCs) from somatic cells is generally a long process with only a few rare cells undergoing the reprogramming process (Hanna et al). For...

May 21, 2013 | Pluripotent Stem Cells

Original article from STEM CELLS

“HPSC Models of Fanconi Anemia Deficiency Reveal an Important Role for Fanconi Anemia Proteins in Cellular Reprogramming and Survival of Hematopoietic Progenitors”

Fanconi anemia (FA) is caused by mutations in replication-dependant repair genes and while several mouse models with targeted deletions...

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