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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

July 25, 2013 | Neural Stem Cells

Original paper “Dynamics of Hippocampal Neurogenesis in Adult Humans” from Cell by Spalding et al.

In the last two decades the central dogma which dictated that no new neurons are born in the adult brain has been refuted, and the mammalian subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus are now...

July 1, 2013 | Pluripotent Stem Cells

“Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single-Step Procedure Using Cell Lineage Transcription Factors”

From Stem Cells Translational Medicine

The degeneration of dopamine (DA) neurons in the substantia nigra leads to Parkinson’s disease (PD), the second most common neurodegenerative...

July 1, 2013 | Pluripotent Stem Cells

“Nicotinamide Overcomes Pluripotency Deficits and Reprogramming Barriers”

From Stem Cells

Current technologies for the efficient large scale production of human induced pluripotent stem cells (iPSCs) are developing daily and are moving steadily towards clinical application, although challenges still exist.  Yee Sook Cho from the Korea Research...

July 1, 2013 | Pluripotent Stem Cells

“Matrix Remodeling Maintains Embryonic Stem Cell Self-Renewal by Activating Stat3”

From Stem Cells

Previous studies from the laboratory of Joel Voldman at the Massachusetts Institute of Technology, USA have shown that extracellular matrix (ECM) remodelling is necessary for mouse embryonic stem cell (mESC) self-renewal (Przybyla and Voldman). ...

July 1, 2013 | Neural Stem Cells

“Lineage-Specific Purification of Neural Stem-Progenitor Cells from Differentiated Mouse Induced Pluripotent Stem Cells”

From Stem Cells Translational Medicine.

While protocols for the differentiation of specific cell lineages from pluripotent cell types abound; the problem of the purification of these cells still remains unsolved.  ...

July 1, 2013 | Pluripotent Stem Cells

“Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer”

Few papers have received more attention than the recent study from the laboratory of Shoukhrat Mitalipov at the Oregon Health & Science University, Beaverton, USA in Cell, describing the first derivation of human embryonic stem cells (hESCs) from cloned embryos (Tachibana et al...

July 1, 2013 | Pluripotent Stem Cells

“Highly Efficient Differentiation of Functional Hepatocytes From Human Induced Pluripotent Stem Cells”

From Stem Cells Translational Medicine

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have long been postulated as a potential source for hepatocytes; for both regenerative medicine (transplantation and use in bioartificial liver...

July 1, 2013 | Pluripotent Stem Cells

“Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells” and “Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells”

In a collaborative study, published recently in Cell, James A. Thomson, Joseph R. Ecker and Bing Ren have defined the roles of specific epigenetic marks...

July 1, 2013 | Cancer Stem Cells

“Cellular Plasticity Confers Migratory and Invasive Advantages to a Population of Glioblastoma-Initiating Cells that Infiltrate Peritumoral Tissue”

From Stem Cells

Treatment of glioblastoma multiforme (GBM) is often problematic due to infiltration of the peritumoral (PT) parenchyma by tumour cells (Kelly et al, Martiroysan ...

June 25, 2013 | Pluripotent Stem Cells

“Neural Precursor Cells Cultured at Physiologically Relevant Oxygen Tensions Have a Survival Advantage Following Transplantation”

From Stem Cells Translational Medicine

The common culture of cells under atmospheric (20%) as opposed to physiological oxygen levels (for example, 13% in oxygenated arterial blood, and 0.5-8%...