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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

September 13, 2013 | Pluripotent Stem Cells

A recent paper in Nature from Spanish scientists at the Spanish National Cancer Research Center (CNIO) reports the reprogramming of cells to generate induced pluripotent stem cells (iPSCs) in adult micein vivo. This work, led by Manuel Serrano who heads the Tumour suppression Group at CNIO, advances the current knowledge of iPSCs by showing that there may be no need to remove...

September 13, 2013 | Pluripotent Stem Cells

“Vascularized and functional human liver from an iPSC-derived organ bud transplant”  

The ex vivo manufacture of organs destined for use as transplants has gained much momentum following a recent paper in Nature, in which scientists from multiple centres in Japan have reported the generation of three-dimensional (3D) vascularised and functional human liver tissue...

September 6, 2013 | Pluripotent Stem Cells

Nanog is oft the first transcription factor to come to mind when the word pluripotency is mentioned, and several studies have suggested that its expression ranges from high to low in ESCs grown in classic feeder-based systems with serum + LIF (Young) with a fraction of cells also observed to fluctuate from a Nanog low to Nanog high state (Chambers et al).   This metastability was...

September 6, 2013 | Haematopoetic Stem Cells

Two recent studies in Science reporting the outcome of lentivirally-mediated gene correction in hematopoietic stem cells (HSCs) to treat human patients have potentially ushered in a new era of safe and effective gene therapy.   Herein, we report on these exciting new clinical findings, both from the laboratory of Luigi Naldini at the San Raffaele...

September 6, 2013 | Pluripotent Stem Cells

The generation of induced pluripotent stem cells (iPSCs) generally relies on the ectopic expression of pluripotency associated transcription factors. However, some pioneering studies have shown that some of these factors can be replaced by small molecule drugs, which are non-immunogenic, cost-effective, and easily synthesized, preserved, and standardised (Zhu et al). Now for the first time, in...

July 30, 2013 | Pluripotent Stem Cells

“Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers”

OCT4 is generally understood as being a hugely important transcription factor associated with pluripotent stem cells and its expression in somatic cells can allow for the derivation of induced pluripotent stem cells (iPSCs) (Li et al and Zhu et al). Upon screening for factors which may substitute for...

July 30, 2013 | Pluripotent Stem Cells

“Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells”

The problem of potentially tumorigenic cells contained within differentiated cultures of human pluripotent stem cells is one of the major obstacles for the transition of stem cell therapy from the laboratory to the clinic. Cell surface markers have...

July 30, 2013 | Pluripotent Stem Cells

“Awakened by Cellular Stress: Isolation and Characterization of a Novel Population of Pluripotent Stem Cells Derived from Human Adipose Tissue”

Using adult stem cells for regenerative purposes faces many problems; one of which is low cell survival and engraftment, due in part to the cellular stresses generated during the process. Challenging both haematopoietic stem cells (HSCs...

July 25, 2013 | Pluripotent Stem Cells

“Induced Pluripotent Stem Cells with a Mitochondrial DNA Deletion” and ““Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS”

Mitochondrial defects are associated with common diseases as well as rare genetic disorders which result when abnormal mitochondria accumulate and manifest as an unhealthy...

July 25, 2013 | Mesenchymal Stem Cells

“Natriuretic Peptide Receptor A Signaling Regulates Stem Cell Recruitment and Angiogenesis: A Model to Study Linkage Between Inflammation and Tumorigenesis”

Natriuretic peptide receptor A (NPRA) is expressed on cells in inflamed or injured tissues and in tumours (Kong et al and Wang et al) and through cGMP-dependent protein kinase (PKG) signalling (Airhart et al and Chen et al...

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