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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

October 25, 2013 | Adipose Stem Cells

Adult stem cell therapies usually rely on extraction, purification, expansion and then re-infusion/re-implantation, with each stage entailing their own specific risks and disadvantages.

October 16, 2013 | Pluripotent Stem Cells

Alongside Nanog, Oct4 is one of the quintessential pluripotency associated transcription factors; considered to be the genetic 'master switch' in the establishment of totipotency to pluripotency during the life cycle of mammals (Pesce et al) and presumed to be the most upstream gene in the...

October 16, 2013 | Pluripotent Stem Cells

Original article from Nature

Pluripotent Stem Cell Derived "Minibrains" to Aid Research

The generation of cerebral organoids (or "mini-brains") from pluripotent stem cell sources is one of the most exciting and widely reported recent research articles.   This study from the laboratory of...

October 16, 2013 | Pluripotent Stem Cells

iPSC Perfection?

Since the birth of the field of induced pluripotent stem cells (iPSCs), each passing month has brought forth numerous papers reporting new tweaks to further improve the reprogramming process; a new chemical here, a replacement transcription factor there, each time removing one small barrier, making reprogramming more rapid or uncovering a new piece of...

October 4, 2013 | Mesenchymal Stem Cells

Alterations in the Cellular Immune Compartment of Patients Treated with Third-Party Mesenchymal Stromal Cells Following Allogeneic Hematopoietic Stem Cell Transplantation

From Stem Cells

Allogeneic hematopoietic stem cell transplantation is often complicated by graft-versus-host disease (GVHD) mediated by the donors immune cells (Ferrara et al)...

October 4, 2013 | Neural Stem Cells

Therapeutic Activities of Engrafted Neural Stem/Precursor Cells Are Not Dormant in the Chronically Injured Spinal Cord

From Stem Cells

Neural stem or precursor cells (NSPCs) have tremendous promise for use in cell-based therapies for the treatment of spinal cord injury (SCI) as they have been shown to provide trophic support following transplantation,...

October 4, 2013 | Adipose Stem Cells

Enhancing In Vivo Survival of Adipose-Derived Stromal Cells Through Bcl-2 Overexpression Using a Minicircle Vector

From Stem Cells Translational Medicine

Survival of therapeutically relevant multipotent stem cells, such as human adipose-derived stromal cells (hASCs), is currently a significant hurdle to stem cell therapy.  ...

October 3, 2013 | Muscle Stem Cells

Sustained Release of Bone Morphogenetic Protein 2 via Coacervate Improves the Osteogenic Potential of Muscle-Derived Stem Cells

From Stem Cells Translational Medicine

The group of Johnny Huard at the University of Pittsburgh, USA have previously isolated and characterized muscle-derived stem cells (MDSCs) (Gharaibeh et al...

October 3, 2013 | Pluripotent Stem Cells

"Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons"

From Stem Cells

The replacement of dopaminergic (DA) neurons in the ventral midbrain (VM) is seen as a viable and beneficial treatment in Parkinson's disease (PD...

October 3, 2013 | Pluripotent Stem Cells

“Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single-Step Procedure Using Cell Lineage Transcription Factors”

From Stem Cells Translational Medicine

A study recently published in Stem Cells TM from the group of Tobias Cantz at the Hannover Medical School, Germany has united two exciting...