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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

January 20, 2014 |

Two recent studies in Science reporting the outcome of lentivirally-mediated gene correction in hematopoietic stem cells (HSCs) to treat human patients have potentially ushered in a new era of safe and effective gene therapy. Herein, we report on these exciting new clinical findings, both from the laboratory of Luigi Naldini at the San Raffaele Scientific Institute, Milan, Italy, on the...

January 16, 2014 |

While complex differentiation strategies for embryonic stem cells (ESCs) usually concentrate on the use of new growth factors or combinations of growth factors for the efficient differentiation towards a cell of interest, the growth substrate on which ESCs are differentiated is often not given the attention it deserves. Furthermore, growth factors are known to stimulate the excretion of...

January 13, 2014 |

Chung and Khurana et al from the laboratory of Susan Lindquist at the Whitehead Institute for Biomedical Research, Cambridge, USA have recently published their exciting work on identifying and exploring restorative therapies for Parkinson's disease (PD) through the use of induced pluripotent stem cell (iPSC) based technology with the help of a yeast model system. In their report in Science...

January 10, 2014 |

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders with great similarities; clinical presentation, pathologic findings, genetic origins and, unfortunately, the lack of treatment. Recent studies have implicated the expansion of a GGGGCC hexanucleotide repeat in the first intron/promoter of the C9ORF72 gene (...

January 8, 2014 |

Multiple studies have shown that stem cell treatment can aid the recovery of the heart after acute myocardial infarction (MI) and phase II clinical trials have started as a result (Buxton and Skarlatos).   However, investigations into cell therapies for established or chronic ventricular dysfunction are lacking. The...

November 18, 2013 | Pluripotent Stem Cells

Recent studies on the host immune response to induced pluripotent stem cells (iPSCs) in mice found that while iPSC-derived teratomas raised a potentially deleterious immune response in genetically identical mice (Zhao et al), their derivatives seem to lack this effect (...

November 18, 2013 | Pluripotent Stem Cells

Down's syndrome (DS) is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21 and is the most common chromosome abnormality in humans, associated with physical growth delays and a severe degree of intellectual disability. It is also associated with early aging and related disorders and, as recent research has linked aging to impaired or exhausted stem cells...

November 17, 2013 | Pluripotent Stem Cells

The importance of the cell cycle to human embryonic stem cells (hESCs) is demonstrated by a wealth of data emanating from multiple labs across the world.

October 25, 2013 | Adipose Stem Cells

 Multiple sclerosis (MS) is a neurodegenerative disease characterized by inflammation and scarring throughout the central nervous system (CNS) which currently has no cure (Jadasz et al).

October 25, 2013 | Neural Stem Cells

Stem cell therapy in humans currently relies on the use of immunosuppressants...

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