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Brief reviews of recently published articles, organized by stem cell type.

June 29, 2012 |

 

Neural stem cell (NSC)-based cancer therapeutics show great potential as while they display an inherent tropism for sites of brain injury they also effectively target sites of tumourigenesis through as yet unappreciated mechanisms (Aboody et al 2000 and Aboody et al 2008).   For this reason NSCs could be utilised in gene therapy strategies against various types of...

June 29, 2012 | Pluripotent Stem Cells

 

Ischemic stroke is the rapid loss of brain function due to disturbance in the blood supply to the brain leading to a loss of function in the affected area.   Studies in rodents have shown that embryonic stem cell (ESC) -derived neural stem cells (NSCs) (Daddi et al, Hicks et aland Ramos-Cabrer et al) and human foetal NSCs (Darsalia et al 2007, Darsalia et al 2011 and Kelly et al)can...

June 18, 2012 | Epiblast Stem Cells

 

Studies of the human germ line are, for obvious reasons, difficult to establish and therefore effective in vitro model systems to study the human germ line formation and subsequent specifications are attractive prospects. Primordial germ cells (PGCs) arise from the post-implantation epiblast of the embryo, and stem cells derived from these cells (Epiblast stem cells or EpiSCs...

June 18, 2012 | Pluripotent Stem Cells

 

NANOG, OCT4 and SOX2 are often given the grand title of master regulators of pluripotency, being tightly associated with human embryonic stem cell (hESC) identity and acting as some of the key reprogramming factors used in common protocols for the production of induced pluripotent stem cells (iPSCs).   Studies in mouse ESCs (mESCs) have shown that the loss of each of these genes...

June 18, 2012 | Hair Follicle Stem Cells

 

Adult or tissue-specific stem cells play major roles in tissue regeneration during normal aging and also during disease. However, the complex multi-factor mechanisms which regulate stem cell self-renewal in adult tissues are relatively unknown. To resolve this, researchers from the laboratory of Elaine Fuchs at the Howard Hughes Medical Institute, The Rockefeller University, New York...

June 5, 2012 | Pluripotent Stem Cells

 

Two recent articles in Cell Stem Cell have highlighted a growing trend in induced pluripotent stem cell (iPSC) biology; direct reprogramming of somatic cells to tissue stem cells such as the direct reprogramming of fibroblasts into induced neural stem cells (iNSCs).   Building on work from Sheng Ding and Marius Wernig, who first reprogrammed neural progenitors from fibroblasts (Kim...

June 4, 2012 | Pluripotent Stem Cells

 

Other than purity and optimal functionality, one of the main concerns with the transplantation of embryonic stem cell (ESC)- or induced pluripotent stem cell (iPSC)-derived cells is their potential tumourigenicity in vivo. To address this, researchers from the group of Jun Takahashi from Kyoto University, Japan studied the effect of transplantation of neural progenitor cells...

June 4, 2012 | Pluripotent Stem Cells

 

Neural stem cell (NSC)-based cancer therapeutics show great potential as while they display an inherent tropism for sites of brain injury they also effectively target sites of tumourigenesis through as yet unappreciated mechanisms (Aboody et al 2000 and Aboody et al 2008). For this reason NSCs could be utilised in gene therapy strategies against various types of...

May 31, 2012 | Pluripotent Stem Cells

From Nature 
By Stuart P. Atkinson

Cellular reprogramming through the forced expression of specific transcription factors in somatic cells to produce induced pluripotent stem cells (iPSCs) has been long understood to involve a genome wide change in the chromatin environment from a largely repressive environment, non-conducive to wide-spread gene expression to a largely...

May 31, 2012 | Technology

From Developmental Cell
By Stuart P. Atkinson

Protocols for the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) and the differentiation of pluripotent cells such as iPSCs and embryonic stem cells (ESCs) have taken great strides forward in recent times, increasing the efficiency and the quality of the desired cell product. However, the isolation of...

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